Structure of PDB 4i9o Chain A

Receptor sequence
>4i9oA (length=78) Species: 10090 (Mus musculus) [Search protein sequence]
RKGWHEHVTQDLRSHLVHKLVQAIFPTPDPAALKDRRMENLVAYAKKVEG
DMYESANSRDEYYHLLAEKIYKIQKECE
3D structure
PDB4i9o Ordering a dynamic protein via a small-molecule stabilizer.
ChainA
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.-
2.3.1.48: histone acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 KI1 A I611 L628 Y631 A632 V635 I660 E663 C664 I24 L41 Y44 A45 V48 I73 E76 C77 PDBbind-CN: -logKd/Ki=5.72,Kd=1.9uM
Gene Ontology
Molecular Function
GO:0003712 transcription coregulator activity
GO:0004402 histone acetyltransferase activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:4i9o, PDBe:4i9o, PDBj:4i9o
PDBsum4i9o
PubMed23384013
UniProtP45481|CBP_MOUSE Histone lysine acetyltransferase CREBBP (Gene Name=Crebbp)

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