Structure of PDB 4i7c Chain A

Receptor sequence
>4i7cA (length=188) Species: 9606 (Homo sapiens) [Search protein sequence]
ANSVLFPCKYASSGCEITLPHTEKADHEELCEFRPYSCPCPGASCKWQGS
LDAVMPHLMHQHKSICTLQGEDIVFLATDINLPGAVDWVMMQSCFGFHFM
LVLEKQEKQQFFAIVQLIGTRKQAENFAYRLELNGHRRRLTWEATPRSIH
EGIATAIMNSDCLVFDTSIAQLFAENGNLGINVTISMC
3D structure
PDB4i7c Structure-based design of covalent siah inhibitors.
ChainA
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A S154 C156 L158 D162 I163 V164 F165 L166 T168 A175 V176 D177 W178 V179 M180 E194 N276 S64 C66 L68 D72 I73 V74 F75 L76 T78 A85 V86 D87 W88 V89 M90 E104 N182
BS02 ZN A C128 C135 H147 H152 C38 C45 H57 H62
BS03 ZN A C98 C105 H117 C121 C8 C15 H27 C31
Gene Ontology
Molecular Function
GO:0008270 zinc ion binding
Biological Process
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0007275 multicellular organism development
Cellular Component
GO:0005737 cytoplasm

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External links
PDB RCSB:4i7c, PDBe:4i7c, PDBj:4i7c
PDBsum4i7c
PubMed23891150
UniProtQ8IUQ4|SIAH1_HUMAN E3 ubiquitin-protein ligase SIAH1 (Gene Name=SIAH1)

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