Structure of PDB 4i7b Chain A

Receptor sequence
>4i7bA (length=189) Species: 9606 (Homo sapiens) [Search protein sequence]
ANSVLFPCKYASSGCEITLPHTEKADHEELCEFRPYSCPCPGASCKWQGS
LDAVMPHLMHQHKSITTLQGEDIVFLATDINLPGAVDWVMMQSCFGFHFM
LVLEKQEGHQQFFAIVQLIGTRKQAENFAYRLELNGHRRRLTWEATPRSI
HEGIATAIMNSDCLVFDTSIAQLFAENGNLGINVTISMC
3D structure
PDB4i7b Structure-based design of covalent siah inhibitors.
ChainA
Resolution3.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A L158 D162 I163 V164 F165 L166 T168 V176 D177 W178 V179 M180 N276 L68 D72 I73 V74 F75 L76 T78 V86 D87 W88 V89 M90 N183
BS02 ZN A C128 C135 H147 H152 C38 C45 H57 H62
BS03 ZN A C98 C105 H117 C121 C8 C15 H27 C31
Gene Ontology
Molecular Function
GO:0008270 zinc ion binding
Biological Process
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0007275 multicellular organism development
Cellular Component
GO:0005737 cytoplasm

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Cellular Component
External links
PDB RCSB:4i7b, PDBe:4i7b, PDBj:4i7b
PDBsum4i7b
PubMed23891150
UniProtQ8IUQ4|SIAH1_HUMAN E3 ubiquitin-protein ligase SIAH1 (Gene Name=SIAH1)

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