Structure of PDB 4i6g Chain A

Receptor sequence
>4i6gA (length=476) Species: 10090 (Mus musculus) [Search protein sequence]
ASSVHWFRKGLRLHDNPALLAAVRGARCVRCVYILDPWFAASSSVGINRW
RFLLQSLEDLDTSLRKLNSRLFVVRGQPADVFPRLFKEWGVTRLTFEYDS
EPFGKERDAAIMKMAKEAGVEVVTENSHTLYDLDRIIELNGQKPPLTYKR
FQALISRMELPKKPAVAVSSQQMESCRAEIQENHDDTYGVPSLEELGFPT
EGLGPAVWQGGETEALARLDKHLEANSLLASPTGLSPYLRFGCLSCRLFY
YRLWDLYKKVKRNSTPPLSLFGQLLWREFFYTAATNNPRFDRMEGNPICI
QIPWDRNPEALAKWAEGKTGFPWIDAIMTQLRQEGWIHHLARHAVACFLT
RGDLWVSWESGVRVFDELLLDADFSVNAGSWMWLSCSAFFQQFFHCYCPV
GFGRRTDPSGDYIRRYLPKLKGFPSRYIYEPWNAPESVQKAAKCIIGVDY
PRPIVNHAETSRLNIERMKQIYQQLS
3D structure
PDB4i6g SCFFBXL3 ubiquitin ligase targets cryptochromes at their cofactor pocket.
ChainA
Resolution2.2 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Q307 W310 W338 H373 W392 W415
Catalytic site (residue number reindexed from 1) Q273 W276 W304 H339 W358 W381
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAD A S270 L273 Q307 W310 R311 H373 R376 H377 F399 D405 A406 D407 V410 N411 S414 W415 S236 L239 Q273 W276 R277 H339 R342 H343 F365 D371 A372 D373 V376 N377 S380 W381 MOAD: Kd=40uM
External links
PDB RCSB:4i6g, PDBe:4i6g, PDBj:4i6g
PDBsum4i6g
PubMed23503662
UniProtQ9R194|CRY2_MOUSE Cryptochrome-2 (Gene Name=Cry2)

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