Structure of PDB 4i6b Chain A

Receptor sequence
>4i6bA (length=285) Species: 9606 (Homo sapiens) [Search protein sequence]
RIIVDPTTGKRYSRGKTLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVSK
PHQREKIDKEIELHRILHHKHVVQFYHYFEDKENIYILLEYCSRRSMAHI
LKARKVLTEPEVRYYLRQIVSGLKYLHEQEILHRDLKLGNFFINESMELK
VGDFGLAARLEPLEHRRRTICGTPNYLSPEVLNKQGHGAESDIWALGCVM
YTMLLGRPPFETTNLKETYRSIREARYTMPSSLLAPAKHLIASMLSKNPE
DRPSLDDIIRHDFFTQGFTPDRLSSSCCHTVPDFH
3D structure
PDB4i6b Selective and brain-permeable polo-like kinase-2 (Plk-2) inhibitors that reduce alpha-synuclein phosphorylation in rat brain.
ChainA
Resolution1.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D205 K207 G209 N210 D223 T243
Catalytic site (residue number reindexed from 1) D135 K137 G139 N140 D153 T173
Enzyme Commision number 2.7.11.21: polo kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 11G A L88 C96 A109 V143 L159 E160 C162 F212 L18 C26 A39 V73 L89 E90 C92 F142 MOAD: ic50=1.17uM
PDBbind-CN: -logKd/Ki=5.93,IC50=1.17uM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4i6b, PDBe:4i6b, PDBj:4i6b
PDBsum4i6b
PubMed23794260
UniProtQ9NYY3|PLK2_HUMAN Serine/threonine-protein kinase PLK2 (Gene Name=PLK2)

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