Structure of PDB 4i5w Chain A

Receptor sequence
>4i5wA (length=292) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]
MIEENLKQKIHDKFVAAKKNGHLKVTHAESKKLKDPQTTTQYWVTFAPSL
ALDPFANPDEELVVTEDLNGDGEYKLLLNKFPVVPEHSLLVTSEFKDQRS
ALTPSDLMTAYNVLCSLQGCERYLVFYNCGPHSGSSQDHKHLQIMQMPEK
FIPFQDVLCNGKDHFLPTFNAEPLQDDKVSFAHFVLPLPESSDQVDEDLL
AMCYVSLMQRALTFFQDLTKSYNVLLTKKWICVVPRSHAKSGPPLMLNIN
STGYCGMILVKDREKLENLTEDPHLVDKSLLQCGFPNTAGQK
3D structure
PDB4i5w Structures of yeast Apa2 reveal catalytic insights into a canonical AP4A phosphorylase of the histidine triad superfamily
ChainA
Resolution2.793 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.7.7.5: sulfate adenylyltransferase (ADP).
2.7.7.53: ATP adenylyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PO4 A H152 H265 A266 H132 H238 A239
BS02 AMP A L50 N92 F94 V96 M165 T279 L286 K288 L50 N79 F81 V83 M145 T252 L259 K261
BS03 AMP A F68 N92 K93 S155 S156 H161 Q163 F55 N79 K80 S135 S136 H141 Q143
Gene Ontology
Molecular Function
GO:0003877 ATP:ADP adenylyltransferase activity
GO:0004780 sulfate adenylyltransferase (ADP) activity
GO:0005524 ATP binding
GO:0008796 bis(5'-nucleosyl)-tetraphosphatase activity
GO:0016779 nucleotidyltransferase activity
GO:0016787 hydrolase activity
GO:0033699 DNA 5'-adenosine monophosphate hydrolase activity
Biological Process
GO:0009117 nucleotide metabolic process
GO:0009164 nucleoside catabolic process
GO:0009165 nucleotide biosynthetic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4i5w, PDBe:4i5w, PDBj:4i5w
PDBsum4i5w
PubMed23628156
UniProtP22108|APA2_YEAST Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase 2 (Gene Name=APA2)

[Back to BioLiP]