Structure of PDB 4i5p Chain A

Receptor sequence
>4i5pA (length=284) Species: 9606 (Homo sapiens) [Search protein sequence]
RIIVDPTTGKRYSRGKTLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVSK
PHQREKIDKEIELHRILHHKHVVQFYHYFEDKENIYILLEYCSRRSMAHI
LKARKVLTEPEVRYYLRQIVSGLKYLHEQEILHRDLKLGNFFINESMELK
VGDFGLAARLEPLEHRRRTICGTPNYLSPEVLNKQGHGAESDIWALGCVM
YTMLLGRPPFETTNLKETYRSIREARYTMPSSLLAPAKHLIASMLSKNPE
DRPSLDDIIRHDFFTQGFTPDRLSSSCCHTVPDF
3D structure
PDB4i5p Selective and brain-permeable polo-like kinase-2 (Plk-2) inhibitors that reduce alpha-synuclein phosphorylation in rat brain.
ChainA
Resolution1.738 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D205 K207 G209 N210 D223 T243
Catalytic site (residue number reindexed from 1) D135 K137 G139 N140 D153 T173
Enzyme Commision number 2.7.11.21: polo kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 1D1 A L88 C96 A109 L159 E160 Y161 C162 F212 L18 C26 A39 L89 E90 Y91 C92 F142 MOAD: ic50=0.377uM
PDBbind-CN: -logKd/Ki=6.42,IC50=0.377uM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4i5p, PDBe:4i5p, PDBj:4i5p
PDBsum4i5p
PubMed23794260
UniProtQ9NYY3|PLK2_HUMAN Serine/threonine-protein kinase PLK2 (Gene Name=PLK2)

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