Structure of PDB 4i5m Chain A

Receptor sequence
>4i5mA (length=273) Species: 9606 (Homo sapiens) [Search protein sequence]
RIIVDPTTGKRYSRGKTLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVSK
PHQREKIDKEIELHRILHHKHVVQFYHYFEDKENIYILLEYCSRRSMAHI
LKARKVLTEPEVRYYLRQIVSGLKYLHEQEILHRDLKLGNFFINESMELK
VGDFGLAARLETPNYLSPEVLNKQGHGAESDIWALGCVMYTMLLGRPPFE
TTNLKETYRSIREARYTMPSSLLAPAKHLIASMLSKNPEDRPSLDDIIRH
DFFTQGFTPDRLSSSCCHTVPDF
3D structure
PDB4i5m Selective and brain-permeable polo-like kinase-2 (Plk-2) inhibitors that reduce alpha-synuclein phosphorylation in rat brain.
ChainA
Resolution1.801 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D176 K178 G180 N181 D194 T214
Catalytic site (residue number reindexed from 1) D135 K137 G139 N140 D153 T162
Enzyme Commision number 2.7.11.21: polo kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 R78 A K57 L59 K61 C67 A80 K82 L130 E131 Y132 C133 S134 R136 F183 K16 L18 K20 C26 A39 K41 L89 E90 Y91 C92 S93 R95 F142 MOAD: ic50=0.0088uM
PDBbind-CN: -logKd/Ki=8.06,IC50=8.8nM
BindingDB: IC50=14nM,Ki=<1nM,Kd=0.810000nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4i5m, PDBe:4i5m, PDBj:4i5m
PDBsum4i5m
PubMed23794260
UniProtQ9NYY3|PLK2_HUMAN Serine/threonine-protein kinase PLK2 (Gene Name=PLK2)

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