Structure of PDB 4i54 Chain A

Receptor sequence
>4i54A (length=339) Species: 11676 (Human immunodeficiency virus 1) [Search protein sequence]
VWKDADTTLFCASDAKAHETEVHNVWATHACVPTDPNPQEIHLENVTENF
NMWKNNMVEQMQEDVISLWDQSLQPCVKLTGGSVIKQACPKISFDPIPIH
YCTPAGYVILKCNDKNFNGTGPCKNVSSVQCTHGIKPVVSTQLLLNGSLA
EEEIIIRSENLTNNAKTIIVHLNKSVEINCTRPSNGDIRKAYCEINGTKW
NKVLKQVTEKLKEHFNNKTIIFQPPSGGDLEITMHSFNCRGEFFYCNTTQ
LFNNTCINGTITLPCKIKQIINMWQGTGQAMYAPPIDGKINCVSNITGIL
LTRDGGANNTSNETFRPGGGNIKDNWRSELYKYKVVQIE
3D structure
PDB4i54 Structure-Based Design and Synthesis of an HIV-1 Entry Inhibitor Exploiting X-Ray and Thermodynamic Characterization.
ChainA
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 1C1 A S256 E370 S375 F376 F382 I424 N425 M426 W427 G429 T430 G473 S140 E231 S236 F237 F243 I271 N272 M273 W274 G276 T277 G320 MOAD: Kd=110nM
PDBbind-CN: -logKd/Ki=6.96,Kd=0.11uM
Gene Ontology

View graph for
Cellular Component
External links
PDB RCSB:4i54, PDBe:4i54, PDBj:4i54
PDBsum4i54
PubMed23667716
UniProtQ0ED31

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