Structure of PDB 4i4f Chain A

Receptor sequence
>4i4fA (length=255) Species: 9606 (Homo sapiens) [Search protein sequence]
YEIQRERIELGRCIGEGQFGDVHQGIYMSPALAVAIKTCKNCTSDSVREK
FLQEALTMRQFDHPHIVKLIGVITENPVWIIMELCTLGELRSFLQVRKYS
LDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGL
SKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDV
IGRIENGERLPMPPNCPPTLYSLMTKCWAYDPSRRPRFTELKAQLSTILE
EEKAQ
3D structure
PDB4i4f Structure-based discovery of cellular-active allosteric inhibitors of FAK.
ChainA
Resolution1.75 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D546 A548 R550 N551 D564 K583
Catalytic site (residue number reindexed from 1) D129 A131 R133 N134 D147 K152
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 1BR A M475 L534 H544 R550 N551 L562 G563 D564 D604 M607 F608 M58 L117 H127 R133 N134 L145 G146 D147 D173 M176 F177 MOAD: ic50=0.64uM
PDBbind-CN: -logKd/Ki=6.19,IC50=0.64uM
BindingDB: IC50=2200nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4i4f, PDBe:4i4f, PDBj:4i4f
PDBsum4i4f
PubMed23414845
UniProtQ05397|FAK1_HUMAN Focal adhesion kinase 1 (Gene Name=PTK2)

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