Structure of PDB 4i2j Chain A

Receptor sequence
>4i2jA (length=353) Species: 10090 (Mus musculus) [Search protein sequence]
KISQYACQRRTTLNNYNQLFTDALDILAENDELRENEGSCLAFMRASSVL
KSLPFPITSMKDTEGIPCLGDKVKSIIEGIIEDGESSEAKAVLNDERYKS
FKLFTSVFGVGLKTAEKWFRMGFRTLSKIQSDKSLRFTQMQKAGFLYYED
LVSCVNRPEAEAVSMLVKEAVVTFLPDALVTMTGGFRRGKMTGHDVDFLI
TSPEATEDEEQQLLHKVTDFWKQQGLLLYCDILESTFEKFKQPDALDHFQ
KCFLILKLDHGRVHSEKGKGWKAIRVDLVMCPYDRRAFALLGWTGSRQFE
RDLRRYATHERKMMLDNHALYDRTKRVFLEAESEEEIFAHLGLDYIEPWE
RNA
3D structure
PDB4i2j Structures of Intermediates along the Catalytic Cycle of Terminal Deoxynucleotidyltransferase: Dynamical Aspects of the Two-Metal Ion Mechanism.
ChainA
Resolution2.7 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D343 D345 D434
Catalytic site (residue number reindexed from 1) D195 D197 D277
Enzyme Commision number 2.7.7.31: DNA nucleotidylexotransferase.
3.1.11.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DCP A G332 G333 R336 G341 H342 D343 D345 G449 W450 R454 G184 G185 R188 G193 H194 D195 D197 G292 W293 R297
BS02 ZN A D399 D473 H475 D247 D316 H318
BS03 ZN A D343 D345 D434 D195 D197 D277
BS04 ZN A D343 D345 D195 D197
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0034061 DNA polymerase activity
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:4i2j, PDBe:4i2j, PDBj:4i2j
PDBsum4i2j
PubMed23856622
UniProtP09838|TDT_MOUSE DNA nucleotidylexotransferase (Gene Name=Dntt)

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