Structure of PDB 4i2h Chain A

Receptor sequence
>4i2hA (length=340) Species: 10090 (Mus musculus) [Search protein sequence]
KISQYACQRRTTLNNYNQLFTDALDILAENDELRENEGSCLAFMRASSVL
KSLPFPITSMKDTEGIPCLGDKVKSIIEGIIEDGESSEAKAVLNDERYKS
FKLFTSVFGVGLKTAEKWFRMGFRTLSKIQSDKSLRFTQMQKAGFLYYED
LVSCVNRPEAEAVSMLVKEAVVTFLPDALVTMTGGFRRGKMTGHDVDFLI
TSPEATEDEEQQLLHKVTDFWKQQGLLLYCDILEDHFQKCFLILKLDHGR
VHSEGKGWKAIRVDLVMCPYDRRAFALLGWTGSRQFERDLRRYATHERKM
MLDNHALYDRTKRVFLEAESEEEIFAHLGLDYIEPWERNA
3D structure
PDB4i2h Structures of Intermediates along the Catalytic Cycle of Terminal Deoxynucleotidyltransferase: Dynamical Aspects of the Two-Metal Ion Mechanism.
ChainA
Resolution2.75 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D343 D345 D434
Catalytic site (residue number reindexed from 1) D195 D197 D264
Enzyme Commision number 2.7.7.31: DNA nucleotidylexotransferase.
3.1.11.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A F256 G257 V258 G259 K261 T262 F108 G109 V110 G111 K113 T114
BS02 MG A D343 D345 D195 D197
BS03 ZN A D343 D345 D434 D195 D197 D264
BS04 ZN A D473 H475 D303 H305
BS05 APC A H342 D343 D345 D399 W450 E457 N474 H194 D195 D197 D235 W280 E287 N304
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0034061 DNA polymerase activity
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:4i2h, PDBe:4i2h, PDBj:4i2h
PDBsum4i2h
PubMed23856622
UniProtP09838|TDT_MOUSE DNA nucleotidylexotransferase (Gene Name=Dntt)

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