Structure of PDB 4i1o Chain A

Receptor sequence
>4i1oA (length=177) Species: 9606 (Homo sapiens) [Search protein sequence]
EYDYLFKLLLIGDSGVGKSCLLLRFADDTYTESYISTIGVDFKIRTIELD
GKTIKLQIWDTAGQERFRTITSSYYRGAHGIIVVYDVTDQESYANVKQWL
QEIDRYASENVNKLLVGNKSDLTTKKVVDNTTAKEFADSLGIPFLETSAK
NATNVEQAFMTMAAEIKKRMGLEVLFQ
3D structure
PDB4i1o Mechanism of Rab1b deactivation by the Legionella pneumophila GAP LepB.
ChainA
Resolution2.701 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Q67
Catalytic site (residue number reindexed from 1) Q64
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A S22 T40 D63 S19 T37 D60
BS02 GDP A G18 G20 K21 S22 C23 Y33 N121 K122 D124 L125 S151 A152 K153 G15 G17 K18 S19 C20 Y30 N118 K119 D121 L122 S148 A149 K150
BS03 BEF A S17 G18 K21 S39 T40 S14 G15 K18 S36 T37
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding

View graph for
Molecular Function
External links
PDB RCSB:4i1o, PDBe:4i1o, PDBj:4i1o
PDBsum4i1o
PubMed23288104
UniProtQ9H0U4|RAB1B_HUMAN Ras-related protein Rab-1B (Gene Name=RAB1B)

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