Structure of PDB 4hw7 Chain A

Receptor sequence
>4hw7A (length=289) Species: 9606 (Homo sapiens) [Search protein sequence]
PTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAV
KMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEY
CTYGDLLNFLRRKAEAMLGPSGRPLELRDLLHFSSQVAQGMAFLASKNCI
HRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPE
SIFDSVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQM
AQPAFAPKNIYSIMQACWALEPTHRPTFQQITSFLQEQA
3D structure
PDB4hw7 Design and pharmacology of a highly specific dual FMS and KIT kinase inhibitor.
ChainA
Resolution2.9001 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D778 R782 N783 D796
Catalytic site (residue number reindexed from 1) D153 R157 N158 D171
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 64M A L588 A614 E664 Y665 C666 L785 G795 D796 F797 L23 A49 E99 Y100 C101 L160 G170 D171 F172 PDBbind-CN: -logKd/Ki=7.21,IC50=0.062uM
BindingDB: IC50=62nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway

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Molecular Function
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Biological Process
External links
PDB RCSB:4hw7, PDBe:4hw7, PDBj:4hw7
PDBsum4hw7
PubMed23493555
UniProtP07333|CSF1R_HUMAN Macrophage colony-stimulating factor 1 receptor (Gene Name=CSF1R)

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