Structure of PDB 4hw3 Chain A

Receptor sequence
>4hw3A (length=150) Species: 9606 (Homo sapiens) [Search protein sequence]
GDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGV
QRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISF
GAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFH
3D structure
PDB4hw3 Discovery of potent myeloid cell leukemia 1 (Mcl-1) inhibitors using fragment-based methods and structure-based design.
ChainA
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 19G A F228 M250 V253 R263 T266 L267 F270 F58 M80 V83 R93 T96 L97 F100 MOAD: Ki=0.32uM
PDBbind-CN: -logKd/Ki=6.49,Ki=0.32uM
BindingDB: IC50=400nM,Ki=320nM
Gene Ontology
Biological Process
GO:0042981 regulation of apoptotic process

View graph for
Biological Process
External links
PDB RCSB:4hw3, PDBe:4hw3, PDBj:4hw3
PDBsum4hw3
PubMed23244564
UniProtQ07820|MCL1_HUMAN Induced myeloid leukemia cell differentiation protein Mcl-1 (Gene Name=MCL1)

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