Structure of PDB 4hw2 Chain A

Receptor sequence
>4hw2A (length=149) Species: 9606 (Homo sapiens) [Search protein sequence]
GDELYRQSLEIISRYLREQATGAKDTKPMSGATSRKALETLRRVGDGVQR
NHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGA
FVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV
3D structure
PDB4hw2 Discovery of potent myeloid cell leukemia 1 (Mcl-1) inhibitors using fragment-based methods and structure-based design.
ChainA
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 19H A A227 F228 M231 M250 V253 F254 R263 L267 F270 I294 A55 F56 M59 M78 V81 F82 R91 L95 F98 I122 PDBbind-CN: -logKd/Ki=7.26,Ki=0.055uM
BindingDB: Ki=55nM
Gene Ontology
Biological Process
GO:0042981 regulation of apoptotic process

View graph for
Biological Process
External links
PDB RCSB:4hw2, PDBe:4hw2, PDBj:4hw2
PDBsum4hw2
PubMed23244564
UniProtQ07820|MCL1_HUMAN Induced myeloid leukemia cell differentiation protein Mcl-1 (Gene Name=MCL1)

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