Structure of PDB 4hvk Chain A

Receptor sequence

>4hvkA (length=369) Species: 224325 (Archaeoglobus fulgidus DSM 4304)

AYFDYTSAKPVDERILEAMLPYMTESFGNPSSVHSYGFKAREAVQEAREK
VAKLVNGGGGTVVFTSGATEANNLAIIGYAMRNARKGKHILVSAVEHMSV
INPAKFLQKQGFEVEYIPVGKYGEVDVSFIDQKLRDDTILVSVQHANNEI
GTIQPVEEISEVLAGKAALHIDATASVGQIEVDVEKIGADMLTISSNDIY
GPKGVGALWIRKEAKLQPVILGGGQENGLRSGSENVPSIVGFGKAAEITA
MEWREEAERLRRLRDRIIDNVLKIEESYLNGHPEKRLPNNVNVRFSYIEG
ESIVLSLDMAGIQASTGQPSHVLMACGLKHEEAHGTLLLTLGRYNTDEDV
DRLLEVLPGVIERLRSMSP

3D structure

• PDB: 4hvk Crystal structure and functional studies of an unusual L-cysteine desulfurase from Archaeoglobus fulgidus.
• Chain: A
• Resolution: 1.43 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): H98 D173 A176 D199
• Catalytic site (residue number reindexed from 1): H97 D172 A175 D198
• Enzyme Commision number: 2.8.1.7: cysteine desulfurase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	CA	A	H98 D173 T175	H97 D172 T174
BS02	PMP	A	A69 T70 H98 N149 D173 T175	A68 T69 H97 N148 D172 T174

Gene Ontology

Molecular Function

• GO:0016740 transferase activity
• GO:0030170 pyridoxal phosphate binding
• GO:0031071 cysteine desulfurase activity
• GO:0046872 metal ion binding
• GO:0051537 2 iron, 2 sulfur cluster binding

Biological Process

• GO:0016226 iron-sulfur cluster assembly
• GO:0044571 [2Fe-2S] cluster assembly

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:4hvk, PDBe:4hvk, PDBj:4hvk
• PDBsum: 4hvk
• PubMed: 23160436
• UniProt: O29689|ISCS2_ARCFU Cysteine desulfurase IscS 2 (Gene Name=iscS2)