Structure of PDB 4hvi Chain A

Receptor sequence
>4hviA (length=274) Species: 9606 (Homo sapiens) [Search protein sequence]
TIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQGPDQQR
DFQREIQILKALHSDFIVKYRGVSYLRLVMEYLPSGCLRDFLQRHRARLD
ASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAK
LLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFT
YCDKSCSPSAEFLRMMVPALSRLLELLEEGQRLPAPPACPAEVHELMKLC
WAPSPQDRPSFSALGPQLDMLWSG
3D structure
PDB4hvi 3-Amido Pyrrolopyrazine JAK Kinase Inhibitors: Development of a JAK3 vs JAK1 Selective Inhibitor and Evaluation in Cellular and in Vivo Models.
ChainA
Resolution2.4 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D949 A951 R953 N954 D967
Catalytic site (residue number reindexed from 1) D127 A129 R131 N132 D145
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 19S A L828 G829 V836 A853 K855 M902 E903 Y904 L905 L956 L14 G15 V22 A39 K41 M80 E81 Y82 L83 L134 MOAD: ic50=68.9nM
PDBbind-CN: -logKd/Ki=7.16,IC50=68.9nM
BindingDB: IC50=69nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4hvi, PDBe:4hvi, PDBj:4hvi
PDBsum4hvi
PubMed23214979
UniProtP52333|JAK3_HUMAN Tyrosine-protein kinase JAK3 (Gene Name=JAK3)

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