Structure of PDB 4hva Chain A

Receptor sequence
>4hvaA (length=238) Species: 9606 (Homo sapiens) [Search protein sequence]
FDPAEKYKMDHRRRGIALIFNHERFFWHLTLPERRGTCADRDNLTRRFSD
LGFEVKCFNDLKAEELLLKIHEVSTVSHADADCFVCVFLSHGEGNHIYAY
DAKIEIQTLTGLFKGDKCHSLVGKPKIFIIQACRGNQHDVPVIPYTLPAG
ADFLMCYSVAEGYYSHRETVNGSWYIQDLCEMLGKYGSSLEFTELLTLVN
RKVSQRRVDFCKDPSAIGKKQVPCFASMLTKKLHFFPK
3D structure
PDB4hva Mechanistic and structural understanding of uncompetitive inhibitors of caspase-6.
ChainA
Resolution2.074 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) P62 E63 H121 G122 C163 R164
Catalytic site (residue number reindexed from 1) P32 E33 H91 G92 C133 R134
Enzyme Commision number 3.4.22.59: caspase-6.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A R64 H121 Q161 A162 C163 Y217 S218 H219 R220 T222 F263 C264 K265 R34 H91 Q131 A132 C133 Y164 S165 H166 R167 T169 F210 C211 K212
BS02 4HV A L61 P62 H121 H168 C264 L31 P32 H91 H138 C211 MOAD: Kd=1.3uM
PDBbind-CN: -logKd/Ki=5.89,Kd=1.3uM
Gene Ontology
Molecular Function
GO:0004197 cysteine-type endopeptidase activity
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:4hva, PDBe:4hva, PDBj:4hva
PDBsum4hva
PubMed23227217
UniProtP55212|CASP6_HUMAN Caspase-6 (Gene Name=CASP6)

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