Structure of PDB 4hv4 Chain A

Receptor sequence
>4hv4A (length=465) Species: 214092 (Yersinia pestis CO92) [Search protein sequence]
VRHIHFVGIGGAGMGGIAEVLANEGYQISGSDLAPNSVTQHLTALGAQIY
FHHRPENVLDASVVVVSTAISADNPEIVAAREARIPVIRRAEMLAELMRY
RHGIAVAGTHGKTTTTAMLSSIYAEAGLDPTFVNGGLVKAAGTHARLGSS
RYLIAEADESDASFLHLQPMVAIVTNIEADHMDTYQGDFENLKQTFINFL
HNLPFYGRAVMCIDDPVVRELLPRVGRHITTYGFSDDADVQIASYRQEGP
QGHFTLRRQDKPLIEVTLNAPGRHNALNAAAAVAVATEEGIEDEDILRAL
VGFQGTGRRFDFLGNFPLAPVNGKEGSAMLVDDYGHHPTEVDATIKAARA
GWPDKRIVMLFQPHRYTRTRDLYDDFANVLSQVDVLLMLDVYAAGEPPIP
GADSRALCRTIRNRGKLDPILVPDSESAPEMLAQILNGEDLILVQGAGNI
GKIARKLAEHKLQPQ
3D structure
PDB4hv4 2.25 Angstrom resolution crystal structure of UDP-N-acetylmuramate--L-alanine ligase (murC) from Yersinia pestis CO92 in complex with AMP
ChainA
Resolution2.25 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) K130 T131 L155 E174 H199
Catalytic site (residue number reindexed from 1) K112 T113 L137 E156 H181
Enzyme Commision number 6.3.2.8: UDP-N-acetylmuramate--L-alanine ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AMP A H128 G129 T131 T132 H292 N296 R327 D351 Y352 E358 T362 H110 G111 T113 T114 H274 N278 R309 D333 Y334 E340 T344
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0008763 UDP-N-acetylmuramate-L-alanine ligase activity
GO:0016874 ligase activity
GO:0016881 acid-amino acid ligase activity
Biological Process
GO:0008360 regulation of cell shape
GO:0009058 biosynthetic process
GO:0009252 peptidoglycan biosynthetic process
GO:0051301 cell division
GO:0071555 cell wall organization
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4hv4, PDBe:4hv4, PDBj:4hv4
PDBsum4hv4
PubMed
UniProtQ8ZIE8|MURC_YERPE UDP-N-acetylmuramate--L-alanine ligase (Gene Name=murC)

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