Structure of PDB 4hv3 Chain A

Receptor sequence
>4hv3A (length=268) Species: 3988 (Ricinus communis) [Search protein sequence]
MIFPKQYPIINFTTAGATVQSYTNFIRAVRGRLTTGADVRHEIPVLPNRV
GLPINQRFILVELSNHAELSVTLALDVTNAYVVGYRAGNSAYFFHPDNQE
DAEAITHLFTDVQNRYTFAFGGNYDRLEQLAGNLRENIELGNGPLEEAIS
ALYYYSTGGTQLPTLARSFIICIQMISEAARFQYIEGEMRTRIRYNRRSA
PDPSVITLENSWGRLSTAIQESNQGAFASPIQLQRRNGSKFSVYDVSILI
PIIALMVYRCAPPPSSQF
3D structure
PDB4hv3 Peptide-conjugated pterins as inhibitors of ricin toxin A.
ChainA
Resolution1.54 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) V81 E177 R180
Catalytic site (residue number reindexed from 1) V82 E178 R181
Enzyme Commision number 3.2.2.22: rRNA N-glycosylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 19L A Y80 V81 G121 N122 Y123 I172 S176 R180 W211 R258 Y81 V82 G122 N123 Y124 I173 S177 R181 W212 R259 MOAD: ic50=115uM
PDBbind-CN: -logKd/Ki=3.94,IC50=115uM
Gene Ontology
Molecular Function
GO:0030598 rRNA N-glycosylase activity
Biological Process
GO:0017148 negative regulation of translation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4hv3, PDBe:4hv3, PDBj:4hv3
PDBsum4hv3
PubMed23214944
UniProtP02879|RICI_RICCO Ricin

[Back to BioLiP]