Structure of PDB 4hqr Chain A

Receptor sequence
>4hqrA (length=217) Species: 9606 (Homo sapiens) [Search protein sequence]
TYQYNMNFEKLGKCIIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGF
DVIVYNDCSCAKMQDLLKKASEEDHTNAACFACILLSHGEENVIYGKDGV
TPIKDLTAHFRGDRCKTLLEKPKLFFIQACRGTELYKIPVEADFLFAYST
VPGYYSWRSPGRGSWFVQALCSILEEHGKDLEIMQILTRVNDRVARHFEK
QIPCVVSMLTKELYFSQ
3D structure
PDB4hqr Structural asymmetry of procaspase-7 bound to a specific inhibitor
ChainA
Resolution3.0 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) G85 V86 H144 G145 C186
Catalytic site (residue number reindexed from 1) G29 V30 H88 G89 C130
Enzyme Commision number 3.4.22.60: caspase-7.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A R87 H144 C186 W232 R233 P235 R31 H88 C130 W157 R158 P160
Gene Ontology
Molecular Function
GO:0004197 cysteine-type endopeptidase activity
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4hqr, PDBe:4hqr, PDBj:4hqr
PDBsum4hqr
PubMed23897474
UniProtP55210|CASP7_HUMAN Caspase-7 (Gene Name=CASP7)

[Back to BioLiP]