Structure of PDB 4hp8 Chain A

Receptor sequence
>4hp8A (length=245) Species: 176299 (Agrobacterium fabrum str. C58) [Search protein sequence]
NPFSLEGRKALVTGANTGLGQAIAVGLAAAGAEVVCAARRAPDETLDIIA
KDGGNASALLIDFADPLAAKDSFTDAGFDILVNNAGIIRRADSVEFSELD
WDEVMDVNLKALFFTTQAFAKELLAKGRSGKVVNIASLLSFQGGIRVPSY
TAAKHGVAGLTKLLANEWAAKGINVNAIAPGYIETNNTEALRADAARNKA
ILERIPAGRWGHSEDIAGAAVFLSSAAADYVHGAILNVDGGWLAR
3D structure
PDB4hp8 Crystal structure of a putative 2-deoxy-d-gluconate 3-dehydrogenase from Agrobacterium Tumefaciens (target EFI-506435) with bound NADP
ChainA
Resolution1.35 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) G20 S139 V149 Y152 K156
Catalytic site (residue number reindexed from 1) G18 S137 V147 Y150 K154
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAP A G16 N18 T19 G20 L21 R41 R42 D64 F65 N86 A87 G88 I89 I137 Y152 K156 P182 G183 I185 T187 N189 T190 G14 N16 T17 G18 L19 R39 R40 D62 F63 N84 A85 G86 I87 I135 Y150 K154 P180 G181 I183 T185 N187 T188
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0008678 2-deoxy-D-gluconate 3-dehydrogenase activity
GO:0016491 oxidoreductase activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0051287 NAD binding

View graph for
Molecular Function
External links
PDB RCSB:4hp8, PDBe:4hp8, PDBj:4hp8
PDBsum4hp8
PubMed
UniProtA9CEQ9

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