Structure of PDB 4hos Chain A

Receptor sequence
>4hosA (length=482) Species: 9606 (Homo sapiens) [Search protein sequence]
MSEIRKDTLKAILLELECHFTWNLLKEDIDLFEVEDTIGQQLEFLTTKSR
LALYNLLAYVKHLKGQNKDALECLEQAEEIIQQEHSDKEEVRSLVTWGNY
AWVYYHMDQLEEAQKYTGKIGNVCKKLSSPSNYKLECPETDCEKGWALLK
FGGKYYQKAKAAFEKALEVEPDNPEFNIGYAITVYRLDDSDREGSVKSFS
LGPLRKAVTLNPDNSYIKVFLALKLQDVHAEAEGEKYIEEILDQISSQPY
VLRYAAKFYRRKNSWNKALELLKKALEVTPTSSFLHHQMGLCYRAQMIQI
KKATHNRPKGKDKLKVDELISSAIFHFKAAMERDSMFAFAYTDLANMYAE
GGQYSNAEDIFRKALRLENITDDHKHQIHYHYGRFQEFHRKSENTAIHHY
LEALKVKDRSPLRTKLTSALKKLSTKRLCHNALDVQSLSALGFVYKLEGE
KRQAAEYYEKAQKIDPENAEFLTALCELRLSI
3D structure
PDB4hos Structural basis for viral 5'-PPP-RNA recognition by human IFIT proteins.
ChainA
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna A T37 Q41 K150 G152 G153 Y156 R186 Y250 R253 Y254 K257 F284 H287 Q288 R294 F337 F339 D343 Q377 T37 Q41 K150 G152 G153 Y156 R186 Y250 R253 Y254 K257 F284 H287 Q288 R294 F337 F339 D343 Q377
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0000339 RNA cap binding
GO:0003690 double-stranded DNA binding
GO:0003723 RNA binding
GO:0003727 single-stranded RNA binding
GO:0005515 protein binding
GO:0008266 poly(U) RNA binding
Biological Process
GO:0043123 positive regulation of canonical NF-kappaB signal transduction
GO:0045071 negative regulation of viral genome replication
GO:0045087 innate immune response
GO:0051607 defense response to virus
GO:0051707 response to other organism
Cellular Component
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0008385 IkappaB kinase complex
GO:0015629 actin cytoskeleton
GO:0032587 ruffle membrane
GO:0042995 cell projection
GO:0045177 apical part of cell

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4hos, PDBe:4hos, PDBj:4hos
PDBsum4hos
PubMed23334420
UniProtQ13325|IFIT5_HUMAN Interferon-induced protein with tetratricopeptide repeats 5 (Gene Name=IFIT5)

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