Structure of PDB 4hni Chain A

Receptor sequence
>4hniA (length=284) Species: 9606 (Homo sapiens) [Search protein sequence]
LRVGNKYRLGRKIGSGSFGDIYLGANIASGEEVAIKLECVHIESKFYKMM
QGGVGIPSIKWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLA
DQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDA
RTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLG
SLPWQGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEFSTYLNFCRSLR
FDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNML
3D structure
PDB4hni Structural basis for the potent and selective inhibition of casein kinase 1 epsilon.
ChainA
Resolution2.74 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D128 K130
Catalytic site (residue number reindexed from 1) D119 K121
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 16W A I15 A36 K38 M80 M82 L84 L85 L135 F150 I13 A34 K36 M71 M73 L75 L76 L126 F141 PDBbind-CN: -logKd/Ki=7.49,IC50=32nM
BindingDB: IC50=32nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4hni, PDBe:4hni, PDBj:4hni
PDBsum4hni
PubMed23106386
UniProtP49674|KC1E_HUMAN Casein kinase I isoform epsilon (Gene Name=CSNK1E)

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