Structure of PDB 4hnf Chain A

Receptor sequence
>4hnfA (length=289) Species: 9606 (Homo sapiens) [Search protein sequence]
LRVGNRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVKPQLHIESKI
YKMMQGGVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTV
LLLADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKK
YRDARTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMY
FNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEFATYLNFC
RSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLK
3D structure
PDB4hnf Structural basis for the potent and selective inhibition of casein kinase 1 epsilon.
ChainA
Resolution2.07 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D128 K130
Catalytic site (residue number reindexed from 1) D123 K125
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
2.7.11.26: [tau protein] kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 16W A G16 S17 A36 K38 E52 M80 M82 L85 G14 S15 A34 K36 E47 M75 M77 L80 MOAD: ic50=711nM
PDBbind-CN: -logKd/Ki=6.15,IC50=711nM
BindingDB: IC50=711nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4hnf, PDBe:4hnf, PDBj:4hnf
PDBsum4hnf
PubMed23106386
UniProtP48730|KC1D_HUMAN Casein kinase I isoform delta (Gene Name=CSNK1D)

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