Structure of PDB 4hne Chain A

Receptor sequence
>4hneA (length=353) Species: 9606 (Homo sapiens) [Search protein sequence]
PLGSPEFAAQAQALAAQAAAAAHAAQAHRERNEFPEDPEFEAVVRQAELA
IERCIFPERIYQGSSGSYFVKDPQGRIIAVFKPKNEEPYGHLNPKWTKWL
QKFGRDCLVLNQGYLSEAGASLVDQKLELNIVPRTKVVYLASETFNYSAI
DRVKSRGKRLALRFNRIGLPPKVGSFQLFVEGYKDADYWLRRFEAEPLPE
NTNRQLLLQFERLVVLDYIIRNTDRGNDNWLIKYDCPPVIKVAAIDNGLA
FPLKHPDSWRAYPFYWAWLPQAKVPFSQEIKDLILPKISDPNFVKDLEED
LYELFKKDPGFDRGQFHKQIAVMRGQILNLTQALKDNKSPLHLVQMPPVI
VET
3D structure
PDB4hne Molecular insights into the membrane-associated phosphatidylinositol 4-kinase II alpha.
ChainA
Resolution2.95 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.67: 1-phosphatidylinositol 4-kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP A G133 S134 K152 Q261 F263 V264 I345 D346 G63 S64 K82 Q177 F179 V180 I245 D246
Gene Ontology
Molecular Function
GO:0004430 1-phosphatidylinositol 4-kinase activity

View graph for
Molecular Function
External links
PDB RCSB:4hne, PDBe:4hne, PDBj:4hne
PDBsum4hne
PubMed24675427
UniProtQ9BTU6|P4K2A_HUMAN Phosphatidylinositol 4-kinase type 2-alpha (Gene Name=PI4K2A)

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