Structure of PDB 4hn5 Chain A

Receptor sequence
>4hn5A (length=72) Species: 9606 (Homo sapiens) [Search protein sequence]
KLCLVCSDEASGCHYGVLTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDKI
RRKNCPACRYRKCLQAGMNLEA
3D structure
PDB4hn5 The structural basis of direct glucocorticoid-mediated transrepression.
ChainA
Resolution1.902 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A C431 H432 Y433 K442 K446 C13 H14 Y15 K24 K28 PDBbind-CN: Kd=363nM
BS02 dna A S440 V443 F444 R447 R470 K471 R477 S22 V25 F26 R29 R52 K53 R59 PDBbind-CN: Kd=363nM
BS03 ZN A C421 C424 C441 C3 C6 C23
BS04 ZN A C457 C463 C473 C476 C39 C45 C55 C58
Gene Ontology
Molecular Function
GO:0003700 DNA-binding transcription factor activity
GO:0008270 zinc ion binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:4hn5, PDBe:4hn5, PDBj:4hn5
PDBsum4hn5
PubMed23222642
UniProtP04150|GCR_HUMAN Glucocorticoid receptor (Gene Name=NR3C1)

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