Structure of PDB 4hkq Chain A

Receptor sequence
>4hkqA (length=441) Species: 373193 (Xenotropic MuLV-related virus VP62) [Search protein sequence]
DFPQAWAETGGMGLAVRQAPLIIPLKATSTPVSIKQYPMSQEARLGIKPH
IQRLLDQGILVPCQSPWNTPLLPVKKDYRPVQDLREVNKRVEDIHPTVPN
PYNLLSGLPPSHQWYTVLDLKDAFFCLRLHPTSQPLFAFEWRDQLTWTRL
PQGFKNSPTLFDEALHRDLADFRIQHPDLILLQYVDDLLLAATSEQDCQR
GTRALLQTLGNLGYRASAKKAQICQKQVKYLGYLLKEGQRWLTEARKETV
MGQPTPKTPRQLREFLGTAGFCRLWIPGFAEMAAPLYPLTKTLFNWGPDQ
QKAYQEIKQALLTAPALGLPDLTKPFELFVDEKQGYAKGVLTQKLGPWRR
PVAYLSKKLDPVAAGWPPCLRMVAAIAVLTKDAGKLTMGQPLVILAPHAV
EALVKQPPARMTHYQAMLLDTDRVQFGPVVALNPATLLPLP
3D structure
PDB4hkq Structural analysis of monomeric retroviral reverse transcriptase in complex with an RNA/DNA hybrid
ChainA
Resolution3.04 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.-
2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.1.-.-
3.1.26.4: ribonuclease H.
3.4.23.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna A Y64 L99 V112 D114 R116 V129 P132 Y133 G191 K193 P196 R311 Y325 K397 K398 Y37 L72 V81 D83 R85 V98 P101 Y102 G153 K155 P158 R273 Y287 K357 K358
BS02 dna A Y222 D224 L269 R284 R298 R301 E302 G305 T306 F309 V402 Y184 D186 L231 R246 R260 R263 E264 G267 T268 F271 V362
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0004523 RNA-DNA hybrid ribonuclease activity

View graph for
Molecular Function
External links
PDB RCSB:4hkq, PDBe:4hkq, PDBj:4hkq
PDBsum4hkq
PubMed23382176
UniProtA1Z651|POL_XMRV6 Gag-Pol polyprotein (Gene Name=gag-pol)

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