Structure of PDB 4hiz Chain A

Receptor sequence
>4hizA (length=658) Species: 948870 (Escherichia phage phi92) [Search protein sequence]
WIIDGRNLTFKVTTLPDISKFKNAAFVYERIVGQPLTYVSEGFFDGNLTK
ITDTPFYNAWTQDKTFVYDNVIYAPFMAGERHGVQNLHVAWVKSGDDGQT
WSMPEWLTPIHPDYTADKVNYHCMSMGVCGNRLYAVIETRYLSNMRLKKA
ELWSRPMPYYRRPTGGITISSGSTTATIVLKKHGLKVGDAVNFSNSGATG
VSGNMTVASVINKDTFTVTLARAATSNIDNTGTTWHFGTRFWDSPWEITE
LPDVAYSTNADLCVTETHSFTVIDDDNYTFAVGYHNGDISPRRLGILYFN
NAYSDPSSFTRRTISQEYADNAAEPCIKYYDGILYLTTRGTSTSAAGSTL
AMSADLGENWNYLRFPNNVHHTNLPFAKVGDYLYIFGTERSFGEWEGQEL
DNRYKGTYPRTFMCKINVSSWPVSLSNVQWFNITDQIYQGHIVNSACGVG
SVCVKDGWLYYIFGGEDFLSPWSIGDNSKKLWYKHDGHPADLYSYRLKIT
EHDFVSRDFKYGATPNRTLPVSMGTDGVRHVSAPVTFDNDVQMYSLTVTG
LEHDGTQQSAVRVKLDGDYGVIAKNIPIKNPSEQRLILCGGETPYTTDGS
LLQLYGSNHTYPNRAILYAPGGAYTQNNFMPYLDGQVSLGGASNRWSEVY
ASTGTINT
3D structure
PDB4hiz Crystal Structure of Endosialidase from Phage phi92 that cleaves alpha2,8- and alpha2,9-linked polysialic acid
ChainA
Resolution1.601 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y155 H180 E422 R437 R488
Catalytic site (residue number reindexed from 1) Y57 H82 E324 R339 R390
Enzyme Commision number 3.2.1.129: endo-alpha-sialidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SLB A G298 S300 G200 S202
BS02 SIA A S292 N293 S300 S194 N195 S202
BS03 FRU A Y219 E249 I346 Y121 E151 I248
BS04 CA A T152 P153 F154 H586 A588 D589 T54 P55 F56 H488 A490 D491
Gene Ontology
Molecular Function
GO:0016996 endo-alpha-(2,8)-sialidase activity

View graph for
Molecular Function
External links
PDB RCSB:4hiz, PDBe:4hiz, PDBj:4hiz
PDBsum4hiz
PubMed
UniProtI7HXG2

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