Structure of PDB 4hgt Chain A

Receptor sequence
>4hgtA (length=283) Species: 9606 (Homo sapiens) [Search protein sequence]
YRLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVHPQLHIESKIYKMMQG
GVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQ
MISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDART
HQHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSL
PWQGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEFATYLNFCRSLRFD
DKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLK
3D structure
PDB4hgt Structure-Based Design of Potent and Selective CK1 gamma Inhibitors.
ChainA
Resolution1.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D128 K130
Catalytic site (residue number reindexed from 1) D117 K119
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
2.7.11.26: [tau protein] kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 15G A I15 G18 I23 A36 K38 M82 L85 L135 I148 D149 I7 G10 I15 A28 K30 M71 L74 L124 I137 D138 PDBbind-CN: -logKd/Ki=7.40,IC50=0.04uM
BindingDB: IC50=40nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4hgt, PDBe:4hgt, PDBj:4hgt
PDBsum4hgt
PubMed24900428
UniProtP48730|KC1D_HUMAN Casein kinase I isoform delta (Gene Name=CSNK1D)

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