Structure of PDB 4hdt Chain A

Receptor sequence
>4hdtA (length=340) Species: 1078020 (Mycolicibacterium thermoresistibile ATCC 19527) [Search protein sequence]
NEDVLVNVEGGVGLLTLNRPKAINSLTHGMVTTMAERLAAWENDDSVRAV
LLTGAGERGLCAGGDVVAIYHSAKADGAEARRFWFDEYRLNAHIGRYPKP
YVSIMDGIVMGGGVGVGAHGNVRVVTDTTKMAMPEVGIGFIPDVGGTYLL
SRAPGKLGLHAALTGAPFSGADAIVMGFADHYVPHDKIDEFTRAVIADGV
DAALAAHAQEPPASPLAEQRSWIDECYTGDTVADIIAALRAHDAPAAGEA
ADLIATRSPIALSVTLESVRRAAKLQSLEDTLRQEYRVSCASLKSHDLVE
GIRAQLVNPKWRPATLAEVTEADVEAYFAPVDPELTFEGE
3D structure
PDB4hdt Increasing the structural coverage of tuberculosis drug targets.
ChainA
Resolution1.6 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) G68 I73 W88 Y92 G116 G119 E139 P146 D147 R287
Catalytic site (residue number reindexed from 1) G64 I69 W84 Y88 G112 G115 E135 P142 D143 R283
Enzyme Commision number 3.1.2.4: 3-hydroxyisobutyryl-CoA hydrolase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A E46 H97 E348 E42 H93 E340
BS02 ZN A E61 H189 E57 H185
BS03 ZN A H32 E83 H28 E79
Gene Ontology
Molecular Function
GO:0003860 3-hydroxyisobutyryl-CoA hydrolase activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0006574 valine catabolic process
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4hdt, PDBe:4hdt, PDBj:4hdt
PDBsum4hdt
PubMed25613812
UniProtG7CC99

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