Structure of PDB 4hda Chain A

Receptor sequence
>4hdaA (length=267) Species: 9606 (Homo sapiens) [Search protein sequence]
RPSSSMADFRKFFAKAKHIVIISGAGVSAESGVPTFRGAGGYWRKWQAQD
LATPLAFAHNPSRVWEFYHYRREVMGSKEPNAGHRAIAECETRLGKQGRR
VVVITQNIDELHRKAGTKNLLEIHGSLFKTRCTSCGVVAENYKSPICPAL
SGKGAPEPGTQDASIPVEKLPRCEEAGCGGLLRPHVVWFGENLDPAILEE
VDRELAHCDLCLVVGTSSVVYPAAMFAPQVAARGVPVAEFNTETTPATNR
FRFHFQGPCGTTLPEAL
3D structure
PDB4hda A molecular mechanism for direct sirtuin activation by resveratrol.
ChainA
Resolution2.601 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) P68 T69 F70 R71 N141 D143 H158
Catalytic site (residue number reindexed from 1) P34 T35 F36 R37 N107 D109 H124
Enzyme Commision number 2.3.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A E225 N226 E191 N192
BS02 ZN A C166 C207 C212 C132 C173 C178
Gene Ontology
Molecular Function
GO:0036054 protein-malonyllysine demalonylase activity
GO:0036055 protein-succinyllysine desuccinylase activity
GO:0070403 NAD+ binding

View graph for
Molecular Function
External links
PDB RCSB:4hda, PDBe:4hda, PDBj:4hda
PDBsum4hda
PubMed23185430
UniProtQ9NXA8|SIR5_HUMAN NAD-dependent protein deacylase sirtuin-5, mitochondrial (Gene Name=SIRT5)

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