Structure of PDB 4hcx Chain A

Receptor sequence
>4hcxA (length=402) Species: 1773 (Mycobacterium tuberculosis) [Search protein sequence]
PKIKVSGPVVELDGDEMTRVIWKLIKDMLILPYLDIRLDYYDLGIEHRDA
TDDQVTIDAAYAIKKHGVGVKCATITPDEARVEEFNLKKMWLSPNGTIRN
ILGGTIFREPIVISNVPRLVPGWTKPIVIGRHAFGDQYRATNFKVDQPGT
VTLTFTPADGSAPIVHEMVSIPEDGGVVLGMYNFKESIRDFARASFSYGL
NAKWPVYLSTKNTILKAYDGMFKDEFERVYEEEFKAQFEAAGLTYEHRLI
DDMVAACLKWEGGYVWACKNYDGDVQSDTVAQGYGSLGLMTSVLMTADGK
TVEAEAAHGTVTRHYRQYQAGKPTSTNPIASIFAWTRGLQHRGKLDGTPE
VIDFAHKLESVVIATVESGKMTKDLAILIGPEQDWLNSEEFLDAIADNLE
KE
3D structure
PDB4hcx Structural, Kinetic and Chemical Mechanism of Isocitrate Dehydrogenase-1 from Mycobacterium tuberculosis.
ChainA
Resolution2.18 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 1.1.1.42: isocitrate dehydrogenase (NADP(+)).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN A D278 D282 D274 D278
BS02 NDP A A77 T78 T80 E309 H312 G313 T314 V315 R317 H318 N331 A73 T74 T76 E305 H308 G309 T310 V311 R313 H314 N327
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0004450 isocitrate dehydrogenase (NADP+) activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016491 oxidoreductase activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0046872 metal ion binding
GO:0051287 NAD binding
Biological Process
GO:0006097 glyoxylate cycle
GO:0006099 tricarboxylic acid cycle
GO:0006102 isocitrate metabolic process
Cellular Component
GO:0005886 plasma membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4hcx, PDBe:4hcx, PDBj:4hcx
PDBsum4hcx
PubMed23409873
UniProtP9WKL1|IDH_MYCTU Isocitrate dehydrogenase [NADP] (Gene Name=icd)

[Back to BioLiP]