Structure of PDB 4hab Chain A

Receptor sequence
>4habA (length=223) Species: 9606 (Homo sapiens) [Search protein sequence]
DCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDK
YGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPN
SLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSA
IILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEY
GCCKELASRLRYARTMVDKLLSS
3D structure
PDB4hab Development of cyclic peptomer inhibitors targeting the polo-box domain of polo-like kinase 1.
ChainA
Resolution2.65 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.21: polo kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A K413 W414 D416 Y485 H489 L490 L491 R516 F535 H538 K540 K43 W44 D46 Y115 H119 L120 L121 R146 F165 H168 K170
BS02 peptide A D449 S450 Y462 L491 D79 S80 Y92 L121
External links
PDB RCSB:4hab, PDBe:4hab, PDBj:4hab
PDBsum4hab
PubMed23498919
UniProtP53350|PLK1_HUMAN Serine/threonine-protein kinase PLK1 (Gene Name=PLK1)

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