Structure of PDB 4h9g Chain A

Receptor sequence
>4h9gA (length=404) Species: 274 (Thermus thermophilus) [Search protein sequence]
KGEFVRTKPHVNVGTIGHVDHGKTTLTAALTYVAAAENPNVEVKDYGDID
KAPEERARGITINTAHVEYETAKRHYSHVDCPGHADYIKNMITGAAQMDG
AILVVSAADGPMPQTREHILLARQVGVPYIVVFMNKVDMVDDPELLDLVE
MEVRDLLNQYEFPGDEVPVIRGSALLALEQMHRNPKTRRGENEWVDKIWE
LLDAIDEYIPTPVRDVDKPFLMPVEDVFTITGRGTVATGRIERGKVKVGD
EVEIVGLAPETRKTVVTGVEMHRKTLQEGIAGDNVGVLLRGVSREEVERG
QVLAKPGSITPHTKFEASVYVLKKEEGGRHTGFFSGYRPQFYFRTTDVTG
VVQLPPGVEMVMPGDNVTFTVELIKPVALEEGLRFAIREGGRTVGAGVVT
KILE
3D structure
PDB4h9g Identifying ligand-binding hot spots in proteins using brominated fragments.
ChainA
Resolution1.93 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) D21 K24 T25 T62 H85
Catalytic site (residue number reindexed from 1) D20 K23 T24 T61 H84
Enzyme Commision number 3.6.5.3: protein-synthesizing GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GNP A V20 D21 G23 K24 T25 T26 Y47 I61 T62 G84 N136 K137 D139 M140 S174 L176 V19 D20 G22 K23 T24 T25 Y46 I60 T61 G83 N135 K136 D138 M139 S173 L175
BS02 MG A T25 T62 T24 T61
BS03 14J A F229 I231 R234 V237 G269 E271 G287 F228 I230 R233 V236 G268 E270 G286
Gene Ontology
Molecular Function
GO:0003746 translation elongation factor activity
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0006412 translation
GO:0006414 translational elongation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4h9g, PDBe:4h9g, PDBj:4h9g
PDBsum4h9g
PubMed23989163
UniProtP60338|EFTU1_THETH Elongation factor Tu-A (Gene Name=tufA)

[Back to BioLiP]