Structure of PDB 4h71 Chain A

Receptor sequence
>4h71A (length=222) Species: 9606 (Homo sapiens) [Search protein sequence]
DCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDK
YGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPN
SLMKKITLLKYFRNYMSEHLLKAGANITPREDELARLPYLRTWFRTRSAI
ILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYG
CCKELASRLRYARTMVDKLLSS
3D structure
PDB4h71 Thymoquinone Blocks pSer/pThr Recognition by Plk1 Polo-Box Domain As a Phosphate Mimic
ChainA
Resolution1.93 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.21: polo kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PXE A S412 L491 K492 A493 H538 K540 R557 S42 L121 K122 A123 H167 K169 R186 PDBbind-CN: -logKd/Ki=4.45,IC50=35.57uM
External links
PDB RCSB:4h71, PDBe:4h71, PDBj:4h71
PDBsum4h71
PubMed23135290
UniProtP53350|PLK1_HUMAN Serine/threonine-protein kinase PLK1 (Gene Name=PLK1)

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