Structure of PDB 4h5i Chain A

Receptor sequence
>4h5iA (length=344) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
MKFVTASYNVGYPAYGAKFLNNDTLLVAGGGGEGNNGIPNKLTVLRVDPT
KDTEKEQFHILSEFALEDNDDSPTAIDASKGIILVGCNENSTKITQGKGN
KHLRKFKYDKVNDQLEFLTSVDFDASTNADDYTKLVYISREGTVAAIASS
KVPAIMRIIDPSDLTEKFEIETRGEVKDLHFSTDGKVVAYITGSSLEVIS
TVTGSCIARKTDFDKNWSLSKINFIADDTVLIAASLKKGKGIVLTKISIK
SGNTSVLRSKQVTNRFKGITSMDVDMKGELAVLASNDNSIALVKLKDLSM
SKIFKQAHSFAITEVTISPDSTYVASVSAANTIHIIKLPLNYAN
3D structure
PDB4h5i The structure of sec12 implicates potassium ion coordination in sar1 activation.
ChainA
Resolution1.36 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 K A G31 G32 E33 G34 N36 I38 D68 G31 G32 E33 G34 N36 I38 D68
BS02 K A Y137 D178 L179 H180 I222 N223 Y137 D178 L179 H180 I222 N223
Gene Ontology
Molecular Function
GO:0005085 guanyl-nucleotide exchange factor activity

View graph for
Molecular Function
External links
PDB RCSB:4h5i, PDBe:4h5i, PDBj:4h5i
PDBsum4h5i
PubMed23109340
UniProtP11655|SEC12_YEAST Guanine nucleotide-exchange factor SEC12 (Gene Name=SEC12)

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