Structure of PDB 4h4f Chain A

Receptor sequence
>4h4fA (length=239) Species: 9606 (Homo sapiens) [Search protein sequence]
VVGGEDARPHSWPWQISLQYLKNDTWRHTCGGTLIASNFVLTAAHCISNT
RTYRVAVGKNNLEVEDEEGSLFVGVDTIHVHKRWNALLLRNDIALIKLAE
HVELSDTIQVACLPEKDSLLPKDYPCYVTGWGRLWTNGPIADKLQQGLQP
VVDHATCSRIDWWGFRVKKTMVCAGGDGVISACNGDSGGPLNCQLENGSW
EVFGIVSFGSRRGCNTRKKPVVYTRVSAYIDWINEKMQL
3D structure
PDB4h4f Long-range Electrostatic Complementarity Governs Substrate Recognition by Human Chymotrypsin C, a Key Regulator of Digestive Enzyme Activation.
ChainA
Resolution1.9 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H57 D102 N192 G193 D194 S195 G196
Catalytic site (residue number reindexed from 1) H45 D92 N184 G185 D186 S187 G188
Enzyme Commision number 3.4.21.2: chymotrypsin C.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A R23 S26 W27 W29 D116 V120 C122 Y137 S206 W207 R8 S11 W12 W14 D106 V110 C112 Y127 S199 W200
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005515 protein binding
GO:0008233 peptidase activity
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0006874 intracellular calcium ion homeostasis

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Molecular Function
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Biological Process
External links
PDB RCSB:4h4f, PDBe:4h4f, PDBj:4h4f
PDBsum4h4f
PubMed23430245
UniProtQ99895|CTRC_HUMAN Chymotrypsin-C (Gene Name=CTRC)

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