Structure of PDB 4h3z Chain A

Receptor sequence
>4h3zA (length=249) Species: 391038 (Paraburkholderia phymatum STM815) [Search protein sequence]
SMQFDIVTLFPDMFRALTDWGITSRAAKQERYGLRTWNPRDFTTDNYRTI
DDRPYGGGPGMVMLARPLEDAINAAKAAQAEQGIGGARVVMMSPQGATLN
HDKVMRFAAEPGLILLCGRYEAIDQRLIDRVVDEEVSLGDFVLSGGELPA
MALIDAVVRHLPGVLNQDSFVDGLLDCPHYTRPEEYDGVRVPDVLLGGHH
AEIEQWRRREALRNTWLKRPDLIVQARKNKLLSRADEAWLASLAKDASK
3D structure
PDB4h3z Combining functional and structural genomics to sample the essential Burkholderia structome.
ChainA
Resolution2.15 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) P93 E120 R158 D173
Catalytic site (residue number reindexed from 1) P94 E121 R159 D168
Enzyme Commision number 2.1.1.228: tRNA (guanine(37)-N(1))-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAH A M91 S92 P93 G117 Y119 E120 S136 L137 V141 L142 G144 G145 P148 M92 S93 P94 G118 Y120 E121 S137 L138 V142 L143 G145 G146 P149
BS02 SAH A D173 S174 D181 D168 S169 D176
Gene Ontology
Molecular Function
GO:0008168 methyltransferase activity
GO:0052906 tRNA (guanine(37)-N1)-methyltransferase activity
Biological Process
GO:0002939 tRNA N1-guanine methylation
GO:0006400 tRNA modification
GO:0008033 tRNA processing
GO:0032259 methylation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4h3z, PDBe:4h3z, PDBj:4h3z
PDBsum4h3z
PubMed23382856
UniProtB2JF31|TRMD_PARP8 tRNA (guanine-N(1)-)-methyltransferase (Gene Name=trmD)

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