Structure of PDB 4h03 Chain A

Receptor sequence
>4h03A (length=414) Species: 1502 (Clostridium perfringens) [Search protein sequence]
MAFIERPEDFLKDKENAIQWEKKEAERVEKNLDTLEKEALELYKKDSEQI
SNYSQTRQYFYDYQIESNPREKEYKNLRNAISKNKIDKPINVYYFESPEK
FAFNKEIRTENQNEISLEKFNELKETIQDKLFKQDGFKDVSLYEPGNGDE
KPTPLLIHLKLPKNTGMLPYINSNDVKTLIEQDYSIKIDKIVRIVIEGKQ
YIKAEASIVNSLDFKDDVSKGDLWGKENYSDWSNKLTPNELADVNDYMRG
GYTAINNYLISNGPLNNPNPELDSKVNNIENALKLTPIPSNLIVYRRSGP
QEFGLTLTSPEYDFNKIENIDAFKEKWEGKVITYPNFISTSIGSVNMSAF
AKRKIILRINIPKDSPGAYLSAIPGYAGEYEVLLNHGSKFKINKVDSYKD
GTVTKLILDATLIN
3D structure
PDB4h03 Arginine ADP-ribosylation mechanism based on structural snapshots of iota-toxin and actin complex
ChainA
Resolution1.75 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) K176
Catalytic site (residue number reindexed from 1) K177
Enzyme Commision number 2.4.2.31: NAD(+)--protein-arginine ADP-ribosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAD A Y251 R295 R296 G298 Q300 E301 N335 T339 R352 E380 Y252 R296 R297 G299 Q301 E302 N336 T340 R353 E381
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
Cellular Component
GO:0005576 extracellular region

View graph for
Molecular Function
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Cellular Component
External links
PDB RCSB:4h03, PDBe:4h03, PDBj:4h03
PDBsum4h03
PubMed23382240
UniProtQ46220

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