Structure of PDB 4gz3 Chain A

Receptor sequence
>4gz3A (length=695) Species: 9606 (Homo sapiens) [Search protein sequence]
PTHADSLNNLANIKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQ
QGKLQEALMHYKEAIRISPTFADAYSNMGNTLKEMQDVQGALQCYTRAIQ
INPAFADAHSNLASIHKDSGNIPEAIASYRTALKLKPDFPDAYCNLAHCL
QIVCDWTDYDERMKKLVSIVADQLEKNRLPSVHPHHSMLYPLSHGFRKAI
AERHGNLCLDKINVLHKPPYEHPKDLKLSDGRLRVGYVSSDFGNHPTSHL
MQSIPGMHNPDKFEVFCYALSPDDGTNFRVKVMAEANHFIDLSQIPCNGK
AADRIHQDGIHILVNMNGYTKGARNELFALRPAPIQAMWLGYPGTSGALF
MDYIITDQETSPAEVAEQYSEKLAYMPHTFFIGDHANMFPHLKKKAVIDF
KHIYDNRIVLNGIDLKAFLDSLPDVKIVKNMPVIPMNTIAEAVIEMINRG
QIQITINGFSISNGLATTQINNKAATGEEVPRTIIVTTRSQYGLPEDAIV
YCNFNQLYKIDPSTLQMWANILKRVPNSVLWLLRFPAVGEPNIQQYAQNM
GLPQNRIIFSPVAPKEEHVRRGQLADVCLDTPLCNGHTTGMDVLWAGTPM
VTMPGETLASRVAASQLTCLGCLELIAKNRQEYEDIAVKLGTDLEYLKKV
RGKVWKQRISSPLFNTKQYTMELERLYLQMWEHYAAGNKPDHMIK
3D structure
PDB4gz3 Structural snapshots of the reaction coordinate for O-GlcNAc transferase.
ChainA
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.1.255: protein O-GlcNAc transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A K396 S494 H496 H517 N557 H558 Y632 T633 K634 Q839 V895 P897 K83 S181 H183 H204 N244 H245 Y319 T320 K321 Q506 V562 P564
BS02 UDP A Q839 K842 L866 V895 A896 K898 H901 H920 T921 T922 D925 Q506 K509 L533 V562 A563 K565 H568 H587 T588 T589 D592 PDBbind-CN: -logKd/Ki=5.74,IC50=1.8uM
BindingDB: IC50=1800nM
BS03 0YT A H498 T560 L653 P656 F694 H920 H185 T247 L340 P343 F381 H587
External links
PDB RCSB:4gz3, PDBe:4gz3, PDBj:4gz3
PDBsum4gz3
PubMed23103939
UniProtO15294|OGT1_HUMAN UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (Gene Name=OGT)

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