Structure of PDB 4gvx Chain A

Receptor sequence

>4gvxA (length=258) Species: 395019 (Burkholderia multivorans ATCC 17616)

MDLNLQDKVVIVTGGASGIGGAISMRLAEERAIPVVFARHAPDGAFLDAL
AQRQPRATYLPVELQDDAQCRDAVAQTIATFGRLDGLVNNAGVNDGIGLD
AGRDAFVASLERNLIHYYAMAHYCVPHLKATRGAIVNISSKTAVTGQGNT
SGYCASKGAQLALTREWAVALREHGVRVNAVIPAEVMTPLYRNWIATFED
PEAKLAEIAAKVPLGRRFTTPDEIADTAVFLLSPRASHTTGEWLFVDGGY
THLDRALV

3D structure

• PDB: 4gvx Crystal structure of a short chain dehydrogenase homolog (target EFI-505321) from burkholderia multivorans, with bound NADP and L-fucose
• Chain: A
• Resolution: 1.499 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): G18 S140 T150 Y153 K157 W194
• Catalytic site (residue number reindexed from 1): G18 S140 T150 Y153 K157 W194
• Enzyme Commision number: 1.1.1.435: L-fucose dehydrogenase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	NAP	A	G14 S17 G18 I19 R39 H40 E63 L64 N90 I138 S139 S140 Y153 K157 P183 V186 T188 L190 Y191	G14 S17 G18 I19 R39 H40 E63 L64 N90 I138 S139 S140 Y153 K157 P183 V186 T188 L190 Y191
BS02	FUL	A	N94 S140 K141 Q147 Y153 A184 E185 Y191 W194	N94 S140 K141 Q147 Y153 A184 E185 Y191 W194

Gene Ontology

Molecular Function

• GO:0000166 nucleotide binding
• GO:0004316 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
• GO:0016491 oxidoreductase activity

Biological Process

• GO:0006004 fucose metabolic process
• GO:0019317 fucose catabolic process

External links

• PDB: RCSB:4gvx, PDBe:4gvx, PDBj:4gvx
• PDBsum: 4gvx
• UniProt: A0A0H3KNE7|LFUCD_BURM1 L-fucose dehydrogenase (Gene Name=BMULJ_04919)