Structure of PDB 4gvc Chain A

Receptor sequence
>4gvcA (length=94) Species: 9606 (Homo sapiens) [Search protein sequence]
GAMGKVTHSIHIEKSDTAADTYGFSLSSVEEDGIRRLYVNSVKETGLASK
KGLKAGDEILEINNRAADALNSSMLKDFLSQPSLGLLVRTYPEL
3D structure
PDB4gvc The structure of the Tiam1 PDZ domain/ phospho-syndecan1 complex reveals a ligand conformation that modulates protein dynamics.
ChainA
Resolution1.54 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A T857 Y858 G859 F860 S861 L862 S863 S864 N876 K879 L915 T21 Y22 G23 F24 S25 L26 S27 S28 N40 K43 L79
Gene Ontology
Molecular Function
GO:0005085 guanyl-nucleotide exchange factor activity
Biological Process
GO:0007264 small GTPase-mediated signal transduction
GO:0090630 activation of GTPase activity

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Molecular Function
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Biological Process
External links
PDB RCSB:4gvc, PDBe:4gvc, PDBj:4gvc
PDBsum4gvc
PubMed23395182
UniProtQ13009|TIAM1_HUMAN Rho guanine nucleotide exchange factor TIAM1 (Gene Name=TIAM1)

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