Structure of PDB 4gv8 Chain A

Receptor sequence
>4gv8A (length=153) Species: 12360 (Dubowvirus dv11) [Search protein sequence]
NTLQVRLLSENARMPERNHKTDAGYDIFSAETVVLEPQEKAVIKTDVAVS
IPEGYVGLLTSRSGVSSKTHLVIETGKIDAGYHGNLGINIKNDAIASNGY
ITPGVFDIKGEIDLSDAIRQYGTYQINEGDKLAQLVIVPIWTPELKQVEE
FES
3D structure
PDB4gv8 Structure and enzymatic mechanism of a moonlighting dUTPase
ChainA
Resolution2.1 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) A25 R64 G66 L73 D81
Catalytic site (residue number reindexed from 1) A23 R62 G64 L71 D79
Enzyme Commision number 3.6.1.23: dUTP diphosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DUP A G78 I80 D81 Y84 G89 G76 I78 D79 Y82 G87 MOAD: Kd=0.32uM
PDBbind-CN: -logKd/Ki=6.49,Kd=0.32uM
BS02 DUP A R64 S65 G66 R62 S63 G64 MOAD: Kd=0.32uM
PDBbind-CN: -logKd/Ki=6.49,Kd=0.32uM
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0004170 dUTP diphosphatase activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0006226 dUMP biosynthetic process
GO:0046081 dUTP catabolic process

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4gv8, PDBe:4gv8, PDBj:4gv8
PDBsum4gv8
PubMed24311572
UniProtQ8SDV3

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