Structure of PDB 4gv0 Chain A

Receptor sequence
>4gv0A (length=354) Species: 9606 (Homo sapiens) [Search protein sequence]
SMKRVQPCSLDPATQKLITNIFSKEMFKNTMALMDLDVKKMPLGKLSKQQ
IARGFEALEALEEALKDGGQSLEELSSHFYTVIPHNFGHSQPPPINSPEL
LQAKKDMLLVLADIELAQALQAVSEQEKTVEEVPHPLDRDYQLLKCQLQL
LDSGAPEYKVIQTYLEQTGSNHRCPTLQHIWKVNQEGEEDRFQAHSKLGN
RKLLWHGTNMAVVAAILTSGLRIMPHSGGRVGKGIYFASENSKSAGYVIG
MKCGAHHVGYMFLGEVALGREHHINTDNPSLKSPPPGFDSVIARGHTEPD
PTQDTELELDGQQVVVPQGQPVPCPEFSSSTFSQSEYLIYQESQCRLRYL
LEVH
3D structure
PDB4gv0 PARP Inhibitor with Selectivity Toward ADP-Ribosyltransferase ARTD3/PARP3
ChainA
Resolution1.9 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S422 Y425 E514
Catalytic site (residue number reindexed from 1) S244 Y247 E336
Enzyme Commision number 2.4.2.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 8ME A D284 L287 D291 H384 G385 Y414 S422 Y425 E514 D106 L109 D113 H206 G207 Y236 S244 Y247 E336 MOAD: ic50=1.3uM
Gene Ontology
Molecular Function
GO:0003950 NAD+-protein poly-ADP-ribosyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:4gv0, PDBe:4gv0, PDBj:4gv0
PDBsum4gv0
PubMed23742272
UniProtQ9Y6F1|PARP3_HUMAN Protein mono-ADP-ribosyltransferase PARP3 (Gene Name=PARP3)

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