Structure of PDB 4gug Chain A

Receptor sequence
>4gugA (length=247) Species: 99287 (Salmonella enterica subsp. enterica serovar Typhimurium str. LT2) [Search protein sequence]
MKTVTVRDLVVGEGAPKIIVSLMGKTITDVKSEALAYREADFDILEWRVD
HFANVTTAESVLEAAGAIREIITDKPLLFTFRSAKAGGEQALTTGQYIDL
NRAAVDSGLVDMIDLELFTGDDEVKATVGYAHQHNVAVIMSNHDFHKTPA
AEEIVQRLRKMQELGADIPKIAVMPQTKADVLTLLTATVEMQERYADRPI
ITMSMSKTGVISRLAGEVFGSAATFGAVKPGQISVADLRTVLTILHQ
3D structure
PDB4gug Reassessing the type I dehydroquinate dehydratase catalytic triad: Kinetic and structural studies of Glu86 mutants.
ChainA
Resolution1.62 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H143 K170
Catalytic site (residue number reindexed from 1) H143 K170
Enzyme Commision number 4.2.1.10: 3-dehydroquinate dehydratase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 3DS A R82 H143 K170 M205 R213 F225 Q236 R82 H143 K170 M205 R213 F225 Q232
Gene Ontology
Molecular Function
GO:0003855 3-dehydroquinate dehydratase activity
GO:0016829 lyase activity
Biological Process
GO:0008652 amino acid biosynthetic process
GO:0009073 aromatic amino acid family biosynthetic process
GO:0009423 chorismate biosynthetic process
GO:0046279 3,4-dihydroxybenzoate biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:4gug, PDBe:4gug, PDBj:4gug
PDBsum4gug
PubMed23341204
UniProtP58687|AROD_SALTY 3-dehydroquinate dehydratase (Gene Name=aroD)

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