Structure of PDB 4gue Chain A

Receptor sequence
>4gueA (length=286) Species: 10090 (Mus musculus) [Search protein sequence]
KEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLY
AMKVLKKATLKVRDRVLVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDL
FTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEG
HIKLTDFGLSKEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFE
MLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANR
LGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKP
3D structure
PDB4gue Identification of quercitrin as an inhibitor of the p90 S6 ribosomal kinase (RSK): structure of its complex with the N-terminal domain of RSK2 at 1.8 A resolution.
ChainA
Resolution1.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D193 K195 E197 N198 D211 T231
Catalytic site (residue number reindexed from 1) D138 K140 E142 N143 D156 T171
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 QCT A F79 K100 V131 L147 D148 L155 E197 L200 L214 F32 K53 V76 L92 D93 L100 E142 L145 L159 MOAD: Kd=5.8uM
PDBbind-CN: -logKd/Ki=5.24,Kd=5.8uM
BS02 MG A K62 Y135 A136 K15 Y80 A81
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4gue, PDBe:4gue, PDBj:4gue
PDBsum4gue
PubMed23385462
UniProtP18654|KS6A3_MOUSE Ribosomal protein S6 kinase alpha-3 (Gene Name=Rps6ka3)

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