Structure of PDB 4gu5 Chain A

Receptor sequence
>4gu5A (length=537) Species: 7227 (Drosophila melanogaster) [Search protein sequence]
TRGANVIWFRHGLRLHDNPALLAALADKDQGIALIPVFIFDGESAGTKNV
GYNRMRFLLDSLQDIDDQLQAATDGRGRLLVFEGEPAYIFRRLHEQVRLH
RICIEQDCEPIWNERDESIRSLCRELNIDFVEKVSHTLWDPQLVIETNGG
IPPLTYQMFLHTVQIIGLPPRPTADARLEDATFVELDPEFCRSLKLFEQL
PTPEHFNVYGDNMGFLAKINWRGGETQALLLLDERLKVEQHAFERGFYLP
NQALPNIHDSPKSMSAHLRFGCLSVRRFYWSVHDLFKNVQLRACVRGVQM
TGGAHITGQLIWREYFYTMSVNNPNYDRMEGNDICLSIPWAKPNENLLQS
WRLGQTGFPLIDGAMRQLLAEGWLHHTLRNTVATFLTRGGLWQSWEHGLQ
HFLKYLLDADWSVCAGNWMWVSSSAFERLLDSSLVTCPVALAKRLDPDGT
YIKQYVPELMNVPKEFVHEPWRMSAEQQEQYECLIGVHYPERIIDLSMAV
KRNMLAMKSLRNSLITPPPHCRPSNEEEVRQFFWLAD
3D structure
PDB4gu5 Updated structure of Drosophila cryptochrome.
ChainA
Resolution2.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Q311 W314 W342 H378 W397 W420
Catalytic site (residue number reindexed from 1) Q309 W312 W340 H376 W395 W418
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A S265 M266 S263 M264
BS02 FAD A S265 S267 L270 Q311 W314 R315 F318 H378 R381 F404 D410 A411 D412 V415 C416 N419 S263 S265 L268 Q309 W312 R313 F316 H376 R379 F402 D408 A409 D410 V413 C414 N417
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003677 DNA binding
GO:0003913 DNA photolyase activity
GO:0005515 protein binding
GO:0009881 photoreceptor activity
GO:0009882 blue light photoreceptor activity
GO:0050660 flavin adenine dinucleotide binding
GO:0071949 FAD binding
Biological Process
GO:0007602 phototransduction
GO:0007623 circadian rhythm
GO:0009416 response to light stimulus
GO:0009588 UV-A, blue light phototransduction
GO:0009637 response to blue light
GO:0009649 entrainment of circadian clock
GO:0009785 blue light signaling pathway
GO:0032922 circadian regulation of gene expression
GO:0042332 gravitaxis
GO:0042752 regulation of circadian rhythm
GO:0043153 entrainment of circadian clock by photoperiod
GO:0045187 regulation of circadian sleep/wake cycle, sleep
GO:0045475 locomotor rhythm
GO:0045892 negative regulation of DNA-templated transcription
GO:0048511 rhythmic process
GO:0048512 circadian behavior
GO:0050958 magnetoreception
GO:0050980 detection of light stimulus involved in magnetoreception
GO:0071000 response to magnetism
GO:0071482 cellular response to light stimulus
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0048471 perinuclear region of cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4gu5, PDBe:4gu5, PDBj:4gu5
PDBsum4gu5
PubMed23518567
UniProtO77059|CRY1_DROME Cryptochrome-1 (Gene Name=cry)

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