Structure of PDB 4gtl Chain A

Receptor sequence
>4gtlA (length=216) Species: 243274 (Thermotoga maritima MSB8) [Search protein sequence]
HHHMKIDILDKGFVELVDVMGNDLSAVRAARVSFDMDEERDRHLIEYLMK
HGHETPFEHIVFTFHVKAPIFVARQWFRHRIASYNELSRYSKLSYEFYIP
SPERLEGYKTTIPPERVTEKISEIVDKAYRTYLELIESGVPREVARIVLP
LNLYTRFFWTVNARSLMNFLNLKADSHAQWEIQQYALAIARIFKEKCPWT
FEAFLKYAYKGDILKE
3D structure
PDB4gtl Folate binding site of flavin-dependent thymidylate synthase.
ChainA
Resolution2.17 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.148: thymidylate synthase (FAD).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAD A R78 H79 R80 I81 N169 L173 R78 H79 R80 I81 N168 L172
BS02 FAD A N85 E86 S88 N85 E86 S88
Gene Ontology
Molecular Function
GO:0004799 thymidylate synthase activity
GO:0008168 methyltransferase activity
GO:0050660 flavin adenine dinucleotide binding
GO:0050797 thymidylate synthase (FAD) activity
GO:0070402 NADPH binding
Biological Process
GO:0006231 dTMP biosynthetic process
GO:0006235 dTTP biosynthetic process
GO:0009165 nucleotide biosynthetic process
GO:0032259 methylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4gtl, PDBe:4gtl, PDBj:4gtl
PDBsum4gtl
PubMed23019356
UniProtQ9WYT0|THYX_THEMA Flavin-dependent thymidylate synthase (Gene Name=thyX)

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